Flow-mediated dilatation (FMD), a measure of endothelial function, was assessed before and after the 6-week periods. A further 44 patients with CAD received either 100 mg kg(-1) day(-1) of betaine or placebo for a 6-week treatment period. In the present study the relationship between FA dose, Hcy lowering and endothelial function in patients with coronary artery disease (CAD) was investigated.Įighty-four patients with CAD received either 400 microg FA or 5 mg placebo daily for a 6-week treatment period. While folic acid (FA) reduces plasma homocysteine (Hcy), whether the simultaneous improvement in endothelial function is dependent on Hcy lowering per se is questionable.
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